HapEvolution Detects gene-gene interactions from case-control haplotype data
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HapEvolution Ranking & Summary

HapEvolution Tags

interaction gene expression gene File Lock duplicate gene sort gene gene sorter analyze gene set gene set analyzer find gene set gene analysis extract gene subset gene subset searcher grab gene subset view gene data display gene data gene expression microarray gene pool Gene Expression data microarray gene analysis gene expression analyzer analyze gene expression gene expression analysis haplotype estimation estimate haplotype common haplotype gene correlation correlate gene analyze gene draw haplotype paint haplotype haplotype gene organization gene visualization compare gene gene comparer gene pattern candidate gene simulate gene mutation gene adjacency gene annotation gene-reaction-protein network Gene Ontology database Gene Ontology create gene network gene network generator gene information management share gene information gene information gene product association haplotype tree gene disease association haplotype inference translate gene identifiers gene identifiers translator gene function prediction gene identification gene match analyze gene structure gene structure analyzer gene mapper gene order comparison compare gene order gene content derived analyze protein-coding gene gene selection gene clustering analyze 16S rRNA gene sequence gene sequence viewer explore gene expression gene expression viewer ancestral gene cluster gene cluster calculator ancestral gene gene cluster analyze gene data gene data analysis analyze gene markers Describe haplotype sequence to haplotype haplotype analysis haplotype block analysis haplotype association test case-control association data gene transfer overlay gene expression data simulate gene network growing generate gene network gene duplication gene frequency data analysis analyze gene frequency data estimate gene diversities test gene diversities Gene Diversity Gene Sequence gene tree gene-gene interaction haplotype association haplotype data find epistatic interactions Y-chromosomal haplotype convert Gene ID Gene ID converter Gene Sequence Name gene clusters reliability modifier gene analysis analyze modifier gene map disease gene disease gene mapper visualize gene explore gene view gene gene expression data analysis latest biodata format math worksheet factory big puffy lips firefox yenc decoder wmv movie downloads family guy imagefap ragnarok darkweiss server jad 2 flash zbd tunnel freedownload nokia 2690 clone cd v sony ericsson vi

HapEvolution Description

Complex diseases involve multiple genes with low penetration which may be distributed over the genome. Most of the current haplotype association methods are typically restricted in length and consist of alleles from contiguous SNPs. These approaches have limited capacity to detect epistasis from multiple gene-gene interactions. Recent evidence has shown that the 3-D structure of chromosomes can play a role in allowing SNPs to interact with genetic elements which are physically separated by great distance. HapEvolution is a professional application designed to implement a cooperative coevolutionary algorithm (CCA) to detect gene-gene interactions from case-control haplotype data; moreover, this algorithm can tolerate up to 15% missing/ambiguous positions in haplotype data arising during haplotype phasing from genotypes. Further, the algorithm can compute epistatic associations from genes spanning multiple chromosomes.

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