MELTING Compute the enthalpy and the entropy of the helix coil transition for a nucleic acid duplex
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entropy enthalpy

MELTING Description

MELTING is an open source application that was designed in order to provide you with a simple means of computing, for a nucleic acid duplex, the enthalpy and the entropy of the helix coil transition and afterwards the melting temperature. Three types of hybridisation are possible: DNA/DNA, DNA/RNA, and RNA/RNA. The program first computes the hybridisation enthalpy and entropy from the elementary parameters of each Crick's pair by the nearest-neighbor method. Then the melting temperature is computed. The set of thermodynamic parameters can be easely changed, for instance following an experimental breakthrough. MELTING 4 is written in ISO C and MELTING 5 in Java.

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