Haploview Haplotype analysis made easy.
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Haploview Tags

analysis Analyze Test haplotype estimation estimate haplotype common haplotype draw haplotype paint haplotype haplotype haplotype tree haplotype inference Describe haplotype sequence to haplotype haplotype analysis haplotype block analysis haplotype association test haplotype association haplotype data Y-chromosomal haplotype

Haploview Description

Haplotype analysis is designed for molecular genetic testing in order to identify DNA segments that share similarities. Haploview has been created to improve the tasks relating to such analysis. The application is Java-based, which makes it cross-platform and there is no need for going through an installation process.Supported file formats and optionsLooks are simple and to the point, with a single panel that accepts the loading of up to five file formats: standard linkage, data dumps from HapMap Project, PHASE or PLINK. There is also support loading multiple files by applying the “-batch” command line. Regardless of the chosen file format loaded in the application the same parameters can be customized. These refer to the pairwise comparison of markers, which can be above a user specified value (the default is set to 500KB). A second parameter refers to the amount of genotypes missing in individuals. Depending on the user-set value, these individuals can be excluded from the analysis. Additional configuration settings are available for some of the supported file formats. In the case of standard linkage users have the possibility to enable association testing, family trio data or load up a test file. After loading such a file there are various displays available, which include LD plot, haplotypes, check markers or tagger (combines pairwise methods with the potential efficiency of multimarker approaches). With PHASE format the HapMap info track can be downloaded if there is an Internet connection. FunctionalityThe program can be used for running LD and haplotype analysis as well as estimate the haplotype frequency in population. The list of functions also supports permutation testing that could reveal association significance. ConclusionHaploview is a program with scientific applications that supports several tasks relating to the process of haplotype analysis. It can be used by students familiar with the subject and it is also flexible in terms of functionality and usability. Reviewed by Ionut Ilascu, last updated on March 7th, 2014

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