CESE CESE - Integrated environment for performing computational simulations using a variety of electrophysiological models
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simulate medical simulation cardiac simulation medical simulation computational simulation

CESE Description

CESE - Integrated environment for performing computational simulations using a variety of electrophysiological models CESE (Cell Electrophysiology Simulation Environment) is a comprehensive framework specifically designed to perform computational electrophysiological simulations, for example, simulations of cardiac myocyte electrical activity. CESE is useful for simulations of action potentials, individual ionic currents, and changes in ionic concentrations.CESE is a cross-platform program and it will run on any system that has Java runtime environment (JRE) version 1.5 (5.0) or above. It was tested on MacOS X, Windows, Linux, Solaris, and AIX.CESE is an integrated environment for performing computational simulations using a variety of electrophysiological models.At this stage CESE allows creation and execution of the single-cell models (containing both Hodgkin-Huxley (HH) and Markovian current formulations). Models of electrical activity of cardiac myocytes with source code are included in the CESE distribution. We hope to extend the number of available models, and add certain neuronal models in the future.The main strength of CESE is in its uniformity - a program interface remains the same for different types of models. You can easily switch between models and compare simulation outputs. Model parameters can be modified, selected for output and/or clamped in the same, standard way.CESE extends the conventional electrophysiological meaning of the "voltage clamp". You can clamp virtually any model variable, including voltage (membrane potential), total or individual ionic currents, ionic concentrations, temperature, gating variables, etc. The clamping commands can be complex piece-wise functions, individually set for the model variable of interest. This opens endless possibilities for the exploration of complex model behavior.CESE provides simple, but efficient data visualizations. Simulation results can be presented in the graphic and tabulated forms. Plots can be customized, and regions of interest zoomed.Even though CESE was not designed to be a data analysis tool, you can generate current-voltage relationships (I-Vs) and calculate statistical parameters for a given signal within the program. You can export your data to ASCII, Axon Text File (ATF), and NetCDF formats to continue analysis in your favorite package. What's New in This Release: · Added GUI to change plot types. 4 plot types are available: Line, Symbol, Histogram, and Column. Issue . (SM) · Added Welcome screen (currently set to CESE survey). (SM) · Fixed empty printing under certain conditions. (SM) · Fixed Lock Record action not staying locked. (SM) · Improved performance in plot legend. (SM) · Changed the default directory location to "My Documents/cese-1.4" in Windows. (SM)

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